Nothando’s rise to television success is a testament to her determination and resilience. Although her audition for a supporting role in Generations: The Legacy didn't match the character, she secured the role of Hlelo on Uzalo in August 2021—a role that deeply resonated with her personal experiences. Initially challenging, her portrayal of Hlelo became a defining moment in her career, highlighting her versatility.

Beyond Uzalo Nothando Ngcobo has explored filmmaking, with her work featured at the Silicon Valley African Film Festival in California. She has also expressed interest in pursuing a journalism career and hinted at possible business ventures, including a skincare line.